How Gabapentin Works for Restless Legs Syndrome (RLS)

gabapentin is often prescribed to treat Restless Legs Syndrome (RLS), particularly in cases where other medications might not be suitable or effective.

Gabapentin can help alleviate the uncomfortable sensations and urge to move the legs that are characteristic of RLS.

How Gabapentin Works for RLS

• Gabapentin is an anticonvulsant and neuropathic pain medication. It’s thought to work by modulating neurotransmitters in the brain, especially those related to pain signaling and nerve activity.
• In the case of RLS, gabapentin appears to reduce nerve excitability and help normalize sensory signals, thereby decreasing the uncomfortable sensations in the legs.

Effectiveness of Gabapentin for RLS

• Studies have shown that gabapentin can reduce the frequency and intensity of RLS symptoms, improve sleep quality, and help patients fall asleep faster.
• It is particularly effective in individuals who have painful RLS or experience significant sleep disturbances due to the condition.
• Gabapentin enacarbil, a prodrug of gabapentin, is specifically approved by the FDA for the treatment of moderate to severe RLS. It is designed to have better absorption and more consistent blood levels than standard gabapentin.